5-amino-1mq
$43.00
- Product Name: 5-amino-1mq
- Molecular Formula: C10H11N2+
- Molecular Weight: 159.21 g/mol
- Research Only: Yes
- Form: Lyophilized Solid
- Storage: Keep refrigerated upon reconstitution
Some COAs may contain redactions of confidential or proprietary information. These redactions do not impact or obscure any analytical data, including compound identity, purity, or test results.
| Title | Range | Discount |
|---|---|---|
| 3-4 vials 5% off | 3 - 4 | 5% |
| Tiered Bulk Discount | 5 - 7 | 10% |
| Tiered Bulk Discount | 8 - 11 | 12% |
| Tiered Bulk Discount | 12 - 15 | 15% |
| Tiered Bulk Discount | 16 + | 20% |
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small molecule within the methylquinolinium class, structurally defined by a quinolinium core with an amino substitution at the 5-position and a methyl group at the 1-position. It has been studied in research settings for its interaction with nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolic processes.
Mechanism of Action
5-Amino-1MQ has been investigated for its ability to inhibit NNMT, which plays a role in nicotinamide metabolism and may influence intracellular nicotinamide adenine dinucleotide (NAD⁺) levels. NAD⁺ is a cofactor involved in redox reactions, DNA repair, and cellular signaling.
Preclinical studies have reported that NNMT inhibition by 5-Amino-1MQ is associated with measurable changes in NAD⁺ levels in cellular models. Additional research suggests that modulation of NNMT activity may influence histone methylation and gene expression patterns related to cellular metabolism.
Metabolic Research
5-Amino-1MQ has been explored in preclinical metabolic models, including diet-induced obesity studies in animals. Some findings have reported associations with changes in body weight, adipose tissue metrics, and cellular lipid metabolism under controlled conditions. These observations are limited to experimental settings and may not translate to human outcomes.
Oncology Research
In preclinical oncology models, 5-Amino-1MQ has been studied for its potential effects on cellular metabolism and gene expression within tumor-associated environments. Research has examined its interaction with cancer-associated fibroblasts and related metabolic pathways, as well as its influence on cellular proliferation in controlled models. These findings are preliminary and require further validation.
Pharmacological Considerations
Ongoing research is evaluating the pharmacokinetic and pharmacodynamic properties of 5-Amino-1MQ, including cellular permeability, metabolic stability, and tissue distribution. Current data are primarily derived from in vitro and animal studies, and comprehensive characterization in human systems has not been established.
5-Amino-1MQ is not approved by the U.S. Food and Drug Administration for human use. Its safety, efficacy, and pharmacological profile have not been established in approved FDA clinical trials. This compound is intended strictly for laboratory research purposes and is not for human or veterinary use.
Lyophilized Peptides
These peptides are freeze-dried, a process that not only extends shelf life but also preserves the purity and integrity of the peptides during storage.
Disclaimer: For Research Purposes only
This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
